Interleukin 1 receptor antagonist (IL1Ra) VNTR polymorphism influences circulatory IL1Ra levels and development of SLE in South Indian Tamils
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منابع مشابه
Association of Interleukin-1 Receptor Antagonist Gene 86bp VNTR Polymorphism with Systemic Lupus Erythematosus in South East of Iran
Article history: Received: 20 July 2013 Accepted: 24 Aug 2013 Available online: 15 Oct 2013 ZJRMS 2014; 16(12): 51-54 Background: Systemic lupus erythematosus (SLE) is an autoimmune disease with unknown etiology. Interleukin-1 receptor antagonist (IL-1Ra) is naturally occurring cytokine that inhibits interleukin-1 (IL-1) activity by binding to the IL-1 receptors without signal transduction. The...
متن کاملassociation between interleukin-1 receptor antagonist (il1rn) variable number of tandem repeats (vntr) polymorphism and pulmonary tuberculosis.
macrophages and t-lymphocytes are involved in immune response to mycobacterium tuberculosis. macrophage produces interleukin (il)-1 as an inflammatory mediator. il-1 receptor antagonist (il1-ra) is a natural antagonist of il-1 receptors. in this study we aimed to examine the possible association between the variable number of tandem repeats (vntr) of the il-1 receptor antagonist (il1rn) gene an...
متن کاملInterleukin-1 receptor antagonist gene VNTR polymorphism is associated with coronary artery disease.
BACKGROUND Coronary Artery Disease (CAD) is the atherosclerosis of coronary arteries that carry blood to the heart muscle. Atherosclerosis is an inflammatory disease. Cytokine gene variations such as those associated with the IL1 family are involved in the pathogenesis of atherosclerosis. OBJECTIVE The purpose of this study was to determine the relationship between IL1 family polymorphisms (I...
متن کاملlack of association between il-1 receptor antagonist gene 86bp vntr polymorphism and leiomyoma
background uterine leiomyoma (uls) is the most common gynecological tumor and a significant health concern for many women .the interleukin-1 receptor antagonist (il-1ra) is a naturally occurring cytokine inhibiting interleukin- 1 (il-1) activity by binding to the il-1 receptors without signal transduction. objectives the aim of this study was to investigate the association between interleukin-1...
متن کاملInterleukin-1 Receptor Antagonist (IL1RA) and Interleukin-4 (IL4) Genes Variable Number Tandem Repeats (VNTRs) Are Associated with Adiposity in Malaysian Subjects
IL1RA intron 2 86-bp repeat and IL4 intron 3 70-bp repeat are VNTRs that have been associated with various diseases, but their role in obesity is elusive. The objective of this study was to investigate the association of IL1RA and IL4 VNTRs with obesity and adiposity in 315 Malaysian subjects (128 M/187 F; 23 Malays/251 ethnic Chinese/41 ethnic Indians). The allelic distributions of IL1RA and I...
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ژورنال
عنوان ژورنال: Indian Journal of Rheumatology
سال: 2016
ISSN: 0973-3698
DOI: 10.1016/j.injr.2015.10.003